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Table 4 Distinct phyletic patterns of non-homologous isofunctional enzymes

From: Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Enzyme (EC)

Examples

Instances in bacteria (out of 607)

Instances in archaea (out of 48)

Instances in eukaryotes (out of 63)

Superoxide dismutase

(EC 1.15.1.1)

SODF_ECOLI

526

23

62

 

SODC_ECOLI

249

3

47

 

SODN_STRSO

32

0

1

 

NEC1_NICLS

6

0

3

Heme oxygenase

(EC 1.14.99.3)

HMOX1_HUMAN

134

0

41

 

ISDI_STAAR

36

0

0

Shikimate kinase

(EC 2.7.1.71)

AROL_ECOLI

553

9

28

 

AROK_METJA

0

39

0

Diacylglycerol kinase

(EC 2.7.1.107)

KDGL_ECOLI

404

0

0

 

DGKG_HUMAN

23

0

59

Fructose bisphosphatase

(EC 3.1.3.11)

F16PA_ECOLI

268

5

54

 

F16P_BACSU

307

4

2

 

Q8U359_PYRFU

19

37

0

Carbonic anhydrase (EC 4.2.1.1)

CYNT_ECOLI

414

17

35

 

CAH_METTE

211

32

10

 

CAH1_HUMAN

88

0

40

Glucose-6-phosphate isomerase (EC 5.3.1.9)

G6PI_HUMAN

547

10

58

 

G6PI_THELI

11

13

0

Lysine---tRNA ligase

(EC 6.1.1.6)

SYK1_ECOLI

551

15

63

 

SYK_AERPE

91

36

0

  1. The data are from the ortholog tables in the KEGG database [20], supplemented with the results of iterative BLAST searches against the NCBI's Reference Sequence database [56].