Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Biology Direct

Table 3 Protein folds most commonly found among non-homologous isofunctional enzymes

Fold	EC1	EC2	EC3	EC4	EC5	EC6	Total
Total number of folds per EC class	46	39	87	34	36	2
TIM beta/alpha-barrel	10	2	29	7	3	-	51*
NAD(P)-binding Rossmann-fold	20	-	5	2	1	-	28
Alpha/beta hydrolases	1	3	8	-	-	-	12*
Ribonuclease H-like motif	-	3	9	-	-	-	12*
Metal-dependent phosphatases	-	-	11	-	-	-	11*
Alpha/alpha toroid	-	-	6	3	1	-	10*
Flavodoxin-like	4	1	4	1	-	-	10
P-loop containing NTPases	1	7	-	1	-	-	9
HAD-like	-	-	7	1	-	-	8
Ferredoxin-like	3	3	-	1	1	-	8

* - These folds are over-represented among the NISE (p < 0.05).
EC1, oxidoreductases; EC2, transferases; EC3, hydrolases; EC4, lyases; EC5, isomerases; EC6, ligases.

ISSN: 1745-6150