Figure 8

Comparison of tumor average chemoresistance in different combined therapies. Comparison of tumor average chemoresistance in different combined therapies. Chemoresistance steadily increases in simultaneous administration, but still more slowly than MTD. After final high dose bolus only 2DG => Rx strategy's tumor remains sensitive. Legend keys are SYNC for simultaneous administration of 2DG and Rx, 2DG => Rx for administration of 2DG followed by Rx, and Rx => 2DG corresponds to administration if Rx followed by 2DG. Red arrows represent final high Rx dose of MTD in one unique dose in order to try tumor eradication.