Figure 6
From: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model
Time-series for the AR kinetics model. Free AR is set to 45 nM as an initial condition; all other variables are initially zero and baseline parameter values are used. Serum T is prescribed at 5 nM, inducing an influx of testosterone, and the model runs to a steady state. (a) Time-series for all model variables - free T, free DHT, T:AR complex, DHT:AR complex, and free AR. (b) Time-series for total T, DHT, and AR concentrations. (a) Time-series for all model variables - free T, free DHT, T:AR complex, DHT:AR complex, and free AR. (b) Time-series for total T, DHT, and AR concentrations.