Figure 13
From: The evolutionary impact of androgen levels on prostate cancer in a multi-scale mathematical model
Evolution of average R t in the state transition model under high and low serum testosterone concentrations for 2 different values of the θ 1 parameter. For θ1 = 20, the more typical pattern is observed with the appearance of AR overexpression occurring later in time but to a greater magnitude under the low androgen environment. A more unique pattern is seen for θ1 = 60. (a) Evolution of average R t for θ1 = 20. (b) Evolution of average R t for θ1 = 60.