Figure 6

Schematic diagram of generalized cancer model with k cancer-stage mutations and m destabilizing mutations, as in Little et al . [6]. This corresponds to a single type, d, destabilizing mutation (d ∈ [1, r]) with m = m _d destabilizing levels. When there is more than one type of destabilizing mutation, there are multiple copies of this diagram, glued together along the topmost axis (of cells that have not acquired a destabilizing mutation), as in Figure 7.