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Figure 3 | Biology Direct

Figure 3

From: The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain

Figure 3

Model for acquisition of the CTD by PriS. Tandem duplication (labelled 1) of a Gins51 ORF found adjacent to a Prim domain ORF in the last common archaeo-eukaryotic ancestor is followed by deletion (labelled 2) of Gins51 A-domain sequences resulting in fusion of Prim domain and B-domain sequences and creation of an ORF encoding a recognisable PriS protein in the last common archaeal ancestor. Subsequent archaeal evolution has seen loss of Gins23 (labelled 3) in many species and loss of the CTD (labelled 4) from PriS in the Thermococcales, including Pyrococcus and Thermococcus species, and the Methanobacteriales. Co-localisation and co-expression of ORFs is also absent in many extant species [13].

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