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Figure 9 | Biology Direct

Figure 9

From: Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization data

Figure 9

Model limits at large ligand concentrations. In the second model in Fig. 8 and Table 1 (solid line here) the dimer term R2X4 causes a below expectation peak (510 instead of 540) at high [ATP]. In the limit of very high [ATP], this model is dominated by the R2X4 term (average mass approaches 180 kDa) because this term partitions more X into a bound state with R than the hexamer R6X8, i.e. 4/2 = 2 > 8/6 = 1.3. These ratios are both 1.5 in the model R2X3.R6X9 (dashed line) which has a balanced population in this limit (with a limiting average mass of 523 kDa). These ratios are 1.5 and 2 in the model R2X3.R6X12 (dotted) which yields pure hexamers (average mass = 540 kDa) in the limit of infinite ATP.

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