Figure 1From: Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization dataThe dNTP supply system. Thick lines are fluxes, thin solid lines are activations, thin dashed lines are inhibitions. Key enzymes are described in the text. An RNR s-site mediated large positive feedback loop ATP → dCTP → dUMP → dTTP → dGTP → dATP terminates when dATP binds the R1 a-site to inhibit all 4 RNR reductions. Models of enzymes of this system will eventually be useful in anticancer drug dose time course optimizations [1].Back to article page