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Figure 1 | Biology Direct

Figure 1

From: Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization data

Figure 1

The dNTP supply system. Thick lines are fluxes, thin solid lines are activations, thin dashed lines are inhibitions. Key enzymes are described in the text. An RNR s-site mediated large positive feedback loop ATP → dCTP → dUMP → dTTP → dGTP → dATP terminates when dATP binds the R1 a-site to inhibit all 4 RNR reductions. Models of enzymes of this system will eventually be useful in anticancer drug dose time course optimizations [1].

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