Products of ubiquitous genes, according to [196] | |||
---|---|---|---|
Protein function | EC number (if available) | Functional dependence on metals | Metals in at least some structures |
Translation and ribosomal biogenesis | |||
Ribosomal proteins (33 in total) | Â | Mg | Mg, Zn (see main text) |
Seryl-tRNA synthetase | 6.1.1.11 | Mg, Zn | |
Methionyl tRNA synthetase | 6.1.1.10 | Mg, Zn | Zn [220] |
Histidyl tRNA synthetase | 6.1.1.21 | Mg | No metals seen |
Tryptophanyl- tRNA synthetase | 6.1.1.2 | Mg, Zn | Mg |
Tyrosyl- tRNA synthetase | 6.1.1.1 | Mg | No metals seen |
Phenylalanyl- tRNA synthetase | 6.1.1.20 | Mg, Zn | Mg |
Aspartyl- tRNA synthetase | 6.1.1.12 | Mg | Mg, Mn [221] |
Valyl-tRNA synthetase | 6.1.1.9 | Mg | Zn [222] |
Isoleucyl-tRNA synthetase | 6.1.1.5 | Mg, Zn | |
Leucyl-tRNA synthetase | 6.1.1.4 | Mg | Zn [225] |
Threonyl-tRNA synthetase | 6.1.1.2 | Mg, Zn | Zn [226] |
Arginyl-tRNA synthetase | 6.1.1.19 | Mg | No metals seen |
Prolyl-tRNA synthetase | 6.1.1.15 | Mg, Zn | |
Alanyl-tRNA synthetase | 6.1.1.7 | Mg, Zn | Mg, Zn [229] |
Translation elongation factor G | 3.6.5.3 | Mg | Mg |
Translation elongation factor P/translation initiatiation factor eIF5-a | Â | Â | Zn (PDB entry 2E9H) |
Translation initiation factor 2 | Â | Â | Zn [230] |
Translation initiation factor IF-1 | Â | Â | No divalent metals |
Pseudouridylate synthase | 5.4.99.12 | Mg, Zn [217] | No metals seen |
Methionine aminopeptidase | 3.4.11.18 | Mn, Zn, or Co | Mn or Zn or Co |
Transcription | |||
Transcription antiterminator NusG | - | - | No metals seen |
DNA-directed RNA polymerase, subunits α, β, β' | 2.7.7.6 | Mg | Mg, Mn, Zn [231] |
Replication | |||
DNA polymerase III, subunit β | 2.7.7.7 | Mg | Mg [232] |
Clamp loader ATPase (DNA polymerase III, subunit γ and τ) | 2.7.7.7. | Mg | Mg, Zn [233] |
Topoisomerase IA | 5.99.1.2 | Mg | No metals seen |
Repair and Recombination | |||
5'-3' exonuclease (including N-terminal domain of PoII) | 3.1.11.a | Mg | Mg |
RecA/RadA recombinase | - | - | Mg |
Chaperone function | |||
Chaperonin GroEL | 3.6.4.9 | Mg | Mg |
O-sialoglycoprotease/apurinic endonuclease | 3.4.24.57 | Zn [239] | Mg, Fe [234] |
Nucleotide and amino acid metabolism metabolism | |||
Thymidylate kinase | 2.7.4.9 | Mg | Mg |
Thioredoxin reductase | 1.8.1.9 | - | No metals seen |
Thioredoxin | Â | - | Zn [235] |
CDP-diglyceride-synthase | 2.7.7.41 | Mg | No entries |
Energy conversion | |||
Phosphomannomutase | 5.4.2.8 | Mg | Mg, Zn [236] |
Catalytic subunit of the membrane ATP synthase | 3.6.1.34 | Mg | Mg |
Proteolipid subunits of the membrane ATP synthase | 3.6.1.34 | - | No metals seen |
Triosephosphate isomerase | 5.3.1.1 | - | No metals seen |
Coenzymes | |||
Glycine hydroxymethyltransferase | 2.1.2.1 | Mg | No metals seen |
Secretion | |||
Preprotein translocase subunit SecY | - | - | Zn [237] |
Signal recognition particle GTPase FtsY | - | - | Mg |
Miscellanous | |||
Predicted GTPase | - | - | No metal ligands in the structures |
Additional ubiquitous gene products from ref. [215] | |||
DNA primase (dnaG) | 2.7.7.- | - | Zn [238] |
S-adenosylmethionine-6-N', N'-adenosyl (rRNA) dimethyltransferase (KsgA) | 2.1.1.48 | Mg | No metals seen |
Transcription pausing, L factor (NusA) | - | - | No metals seen |