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Figure 4 | Biology Direct

Figure 4

From: Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape

Figure 4

Predicted neutral mutations in the signal peptide of pig GDF9. Upper panel. The alignment between the consensus and the Sus scrofa (Ss) sequence shows that 7 positions are divergent. Lower panel. The diagram depicting all possible combinations of these 7 divergent sites (and their effects when introduced in the consensus sequence) is a heptagon. The 7 divergent sites are represented by their numbers, as shown in the alignment. The lines link the mutations together and each black dot at the intersections represents a specific combination. The labels are color-coded according to the signal peptide probabilities (as in previous figures). Green and blue labels, obviously in majority, represent neutral and slightly 'hypermorphic' changes, respectively. For the sake of clarity, a set of 14 combinations were not be placed on the diagram, but they all contained five or six changes each, and all led to at least 109% of the score of the consensus, and would have been color-coded in blue.

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