Query family | Source | Adjacent gene family | Adjacent gene function; reasons if discarded. | Number of occurrences observed |
---|---|---|---|---|
AbrB/MazE | [3] | PIN | Nuclease | 312 |
 |  | MazF | RNA interferase | 97 |
 |  | Fic/Doc | AMPylation enzyme | 48 |
 |  | RelE | RNA interferase | 27 |
ArsR | Table 1 | COG3832 | Aha1 domain | 280 |
 |  | COG0394* | Arsenate reductase arsC; Part of a larger conserved gene associations | 98 |
 |  | COG2217* | Cation transport ATPase; Part of a larger conserved gene associations | 83 |
 |  | COG0798* | Arsenite efflux pump ACR3; Part of a larger conserved gene associations | 74 |
 |  | COG2391* | YeeE/YedE family, DUF395; Part of a larger conserved gene associations | 64 |
 |  | COG1055* | Arsenical pump membrane protein; Part of a larger conserved gene associations | 53 |
RHH | [3] | RelE | RNA interferase | 376 |
 |  | PIN | Nuclease | 335 |
 |  | GNAT | Acetyltransferase | 139 |
 |  | MazF | RNA interferase | 62 |
 |  | COG3505* | TraG/TraD/VirD4 family; Part of a larger conserved gene associations | 58 |
 |  | COG2929 | DUF497 | 55 |
 |  | ParA* | ParA, plasmid partitioning ATPase; Part of a larger conserved gene associations | 54 |
 |  | HicA | RNA interferase | 26 |
 |  | RHH | DNA-binding domain | 23 |
 |  | COG0716* | Flavodoxin; Part of a larger conserved gene associations | 22 |
 |  | COG4962* | Type II/IV secretion system protein; Part of a larger conserved gene associations | 21 |
Fic_Doc | [3] | AbrB | DNA-binding domain | 55 |
 |  | xre | DNA-binding domain | 22 |
 |  | yhfG | Unknown | 11 |
MazF | [3] | AbrB | DNA-binding domain | 107 |
 |  | RHH | DNA-binding domain | 81 |
 |  | MazF/ccd | RNA interferase | 43 |
 |  | XF1863 | Unknown | 29 |
RelE | [3] | xre | Transcriptional regulator | 730 |
 |  | RHH | DNA-binding domain | 510 |
 |  | PHD | DNA-binding domain | 337 |
 |  | COG2856 | Zn peptidase (fused to HTH) | 15 |
 |  | COG1753 | Predicted DNA-binding domain; RHH fold | 10 |
PIN RNA nuclease | [3] | RHH | DNA-binding domain | 366 |
 |  | AbrB | DNA-binding domain | 348 |
 |  | PHD | DNA-binding domain | 285 |
 |  | COG2442 | Protein of unknown function DUF433 | 97 |
 |  | COG2886 | Uncharacterized protein family (UPF0175) | 46 |
 |  | COG2856 | Zn peptidase (fused to HTH) | 42 |
 |  | MazF/ccd | COG5302 | 41 |
 |  | COG1211* | 4-diphosphocytidyl-2-methyl-D-erithritol synthase; Part of a larger conserved gene associations | 39 |
 |  | MerR | Transcriptional regulator | 33 |
 |  | COG1066* | Sms; Part of a large conserved gene associations | 26 |
 |  | COG1092* | SAM-dependent methyltransferase; Part of a larger conserved gene associations | 26 |
 |  | COG2880 | Predicted DNA-binding protein; AbrB superfamily | 24 |
 |  | pfam00155* | Aminotransferase; Part of a larger conserved gene associations | 24 |
 |  | COG5257* | Translation initiation factor 2; Part of a larger conserved gene associations | 20 |
 |  | COG1753 | Predicted DNA-binding domain; RHH fold | 20 |
PHD | [3] | PIN | Nuclease | 276 |
 |  | SMa0917 | PemK/MazFI | 15 |
MNT | Table 1 | HEPN | Unknown | 445 |
HEPN | Table 1 | MNT | Predicted nucleotidyltransferase | 482 |
Xre | [3] | RelE | RNA interferase | 614 |
 |  | HipA | EF-Tu kinase | 244 |
 |  | COG2856 | Zincin protease | 194 |
 |  | xre | A variety of proteins containing xre-like HTH, many fused with various domain, not a distinct set | 97 |
 |  | PIN | Nuclease | 67 |
 |  | DUF397 | Unknown | 64 |
 |  | COG0800* | 2-keto-3-deoxy-6-phosphogluconate aldolase; Part of a larger conserved gene associations | 46 |
 |  | COG3842* | PotA is ABC-type transporter; Part of a larger conserved gene associations | 40 |
 |  | PA2784-like* | A membrane protein, likely an exporter | 36 |
 |  | YoaS-like* | A membrane protein, likely permease | 32 |
 |  | antirepressor | BRO family; KilA – letal to host cells | 30 |
 |  | GNAT | Acetyltransferase | 30 |
 |  | COG3063* | Tfp pilus assembly protein PilF; Part of a large conserved gene associations | 27 |
 |  | PA4076-like* | A membrane protein, likely an exporter | 27 |
 |  | COG4974* | Site-specific recombinase XerD; Apparent phage components with another function | 25 |
 |  | COG0483* | Archaeal fructose-1,6-bisphosphatase; Part of a larger conserved gene associations | 21 |
xre COG5642 subfamily | Â | COG5654 | Predicted transcriptional regulator | 118 |
HipA | [3] | xre | Transcriptional regulator | 333 |
 |  | COG3550 | HipA C-terminal | 51 |
COG2856 | [60] | xre | Transcriptional regulator | 145 |
 |  | PIN | Nuclease | 60 |
 |  | RelE | RNA interferase | 22 |
COG2880 | [13] | PIN | Nuclease | 25 |
COG3832 | Table 1 | ArsR | Transcriptional regulator | 259 |
COG4636 | [13] | COG4636 | Predicted endonuclease | 114 |
COG4679 (RelE family) | [13] | COG5606 | Predicted RNA interferase | 43 |