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Table 1 Proposed order of amino acid incorporation into genetic code, hairpin aminoacylation and stereochemical relationship with anticodon

From: Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code

 

Amino acids in proposed order of incorporation into genetic code

Reported hairpin amino-acylation

Established stereochemical relationship with anticodon

 

glycine

+

 
 

alanine

+

 
 

aspartic acid

+

 

early

valine

+

 
 

proline

  
 

serine

+

 
 

glutamic acid

  
 

threonine

  
 

leucine

 

+

 

arginine

 

codon

 

asparagine

  
 

isoleucine

+

anticodon/codon

 

glutamine

+

-

 

histidine

+

+

 

lysine

  
 

cysteine

+

 

late

phenylalanine

 

+

 

tyrosine

+

+

 

methionine

+

 
 

tryptophan

 

+

  1. Left column: proposed order of incorporation of amino acids into genetic code taken from [9]. Middle column: hairpin aminoacylation data taken from [4]. Right column: stereochemical relationship with anticodon data taken from [27]. Gaps in the table represent those examples where evidence has not been reported or established.