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Figure 5 | Biology Direct

Figure 5

From: Comparable contributions of structural-functional constraints and expression level to the rate of protein sequence evolution

Figure 5

Differences of evolution rates for domains contained in the same multidomain protein and in different proteins, compared to randomized "domain" sequences from multidomain proteins. X-axis: log10 of the ratio of evolution rates of a pair of domains. Y-axis: probability density function. Red, domain pairs within multidomain proteins; black, all possible pairwise combinations of the same domains (from both multidomain proteins and proteins in which the respective domains occur separately); green, randomized domains within multidomain proteins (control for sampling error). The randomized domains were obtained by randomly shuffling the columns in a multidomain protein alignment, and evolution rates were calculated for regions within the original domain boundaries. V a , V m , and V r are the normalized variances of the distributions for all domain pairs, domain pairs within multidomain proteins, and randomized domains, respectively. A – Human proteins: V a /V m /V r = 9.57/1.00/0.40. B – Arabidopsis proteins: V a /V m /V r = 6.14/1.00/0.22.

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