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Figure 3 | Biology Direct

Figure 3

From: Origin of the nucleus and Ran-dependent transport to safeguard ribosome biogenesis in a chimeric cell

Figure 3

An open membrane network sharpens the RanGTP gradient and reduces ribosome chimerism. The three geometries used for the simulations represent intermediate evolutionary stages with progressively more membranes around chromatin. The ratio of the size of the membrane domains and the gaps between them increases from no membranes (no NE, panel A), through 2:1 (B), to 20:1 (C). Although the chromosomes are embedded in a membrane network, there is no selective nuclear transport. Every component can freely diffuse across the gaps between the membrane domains. In the simulations all parameters, except for the geometry, were identical. (D-F) Steady state distribution of RanGTP in the three geometries. (G) Steady state distribution of RanGTP in the three geometries along the line shown in panel (D). The grey line shows the effect in the no NE geometry of decreasing RanGAP levels from 1 to 0.2 um. (H) Chimerism (mitochondrial-RP/host-RP) at steady state with the three different geometries. The black curve (no NE) is the same as the red curve on Figure 2D) (Kf 3.0).

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