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Table 2 Transcription factors with significant target overlap to WT1

From: In silico regulatory analysis for exploring human disease progression

TF Hypergeometric p-value # of genes overlapped Selected KEGG Pathways of targets shared with Wt1
GLI1 0 36 MapK Signalling, Tight Junction, Focal Adhesion
MEF2A 0 29 MapK Signalling, Regulation of Actin Cytoskeleton
NFIC 0 16 MapK Signalling, Regulation of Actin Cytoskeleton, Insulin Signalling
E2F 2.0e-12 52 Calcium Signaling, Notch Signalling, Regulation of Actin Cytoskeleton, WNT Signalling
SRF 1.3e-10 11 MapK Signalling
POU5F1 6.2e-10 38 Neuroactive Ligand Receptor Interaction, MapK Signalling
YY1 3.8e-6 6 MapK Signalling, Regulation of Actin Cytoskeleton
SPI1 1.1e-3 4 --
NANOG 6.7e-3 23 MapK Signalling, Regulation of Actin Cytoskeleton
POU1F1 7.7e-3 1 -
CEBPB 1.1e-2 6 Neuroactive Ligand Receptor Interaction
GATA1 1.5e-2 3 MapK Signalling, Regulation of Actin Cytoskeleton
T3R 1.9e-2 2 MapK Signalling
  1. TFs that have been determined to have significant regulatory overlap to WT1 are given. The p-value for the significance of the overlap as calculated by hypergeometric test is given in column 2. Column 3 lists the number of genes regulated by WT1 and the TF listed in each row. Column 4 lists a selection of the most common pathways in which the targets fall.