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Figure 4 | Biology Direct

Figure 4

From: The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits

Figure 4

Donor lymphocytes are restricted to the peritoneal cavity in NK sufficient but not NK deficient recipients. (A) Experimental design. (B, C) Chimerism assessed from 50–150 days post i.v. vs. i.p. injection of donor BALB/c peritoneal cells into RAG vs. RAG/γc mice. (B) Representative flow cytometry data assessing donor cell chimerism in the lymphocyte gate of recipient spleen and peritoneal cells. Donor cells are defined by the box in each dot plot. (C) The percentage of donor cells in the recipient spleen and peritoneum. Each symbol represents values for an individual mouse. (D) The percentage of donor cells and NK cells in the spleen and peritoneum of RAG/γc, RAG, and anti-asialo GM1 treated RAG mice 2 weeks post injection, i.v. or i.p., of BALB/c peritoneal cells. (E) Chimerism in peripheral blood of individual recipients assessed 10 days post i.p. injection of donor BALB/c peritoneal cells into RAG vs. RAG/γc mice.

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