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Table 4 Hotspots non-randomly associated with non-synonymous sites in tumor suppressor genes according to the NSB test

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

Gene Total number of codons Number of non-synonymous hotspots
TP53 394 59
BRCA1 1864 12
BRCA2 3419 27
p16 157 1
  1. The hotspots are listed in Additional file 3