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Table 3 The NSMC and NSCS test results for BRCA1, BRCA2, and p16 genes

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

Class ID Sites Mutations Hotspots P(H1)/χ2
BRCA1
Synonymous 33 142 16  
Non-synonymous 356 1842 170 0.204/0.006
Nonsense 141 704 74 0.079
BRCA2
Synonymous 55 103 20  
Non-synonymous 797 4871 352 0.071/1.2
Nonsense 179 844 79 0.018
p16
Synonymous 40 63 13  
Non-synonymous 171 321 65 0.388/0.423
Nonsense 18 162 14 0.070
  1. The data for combined spectra from all tumor types are shown. Other designations are as in Table 1.