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Table 2 Combined NSMC and NSCS test results for the TP53 somatic mutations spectra

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

Class ID Sites Mutations Hotspots P(H1)/χ2
Class Ia
Synonymous 157 390 76  
Non-synonymous 527 5710 385 0.990/33.4
Nonsense 78 529 59 0.023
Class II b
Synonymous 172 391 97  
Non-synonymous 495 6109 379 0.991/25.4
Nonsense 72 629 55 0.018
Class III c
Synonymous 217 781 151  
Non-synonymous 617 11819 474 0.994/4.47
Nonsense 88 1158 76 0.011
  1. a Class I: combined mutational spectrum of the tumor types for which H0 is rejected in comparison of synonymous vs. non-synonymous substitutions:brain, liver, lung, colon, mouth, larynx, ovary and skin.
  2. b Class II: combined mutational spectrum of the tumor types for which the test did not find enough evidence, probably, because of the small sample size: bladder, breast, prostate, esophagus, colorectal, hematopoietic, stomach, and pancreas.
  3. c Class III: combined Class I and Class II spectra.
  4. Other designations are as in Table 1.