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Table 1 NSMC and NSCS test results for TP53 somatic mutation spectra (H0: mutational bias; H1: selectional bias)

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

 

Sites

Mutations

Hotspots

P(H1)/χ2

Bladder

Synonymous

61

80

12

 

Non-synonymous

240

775

110

0.107/13.8

Nonsense

36

85

26

0.038

Brain

Synonymous

20

23

2

 

Non-synonymous

199

812

98

0.998/11.2

Nonsense

14

32

5

0.015

Breast

Synonymous

77

108

19

 

Non-synonymous

294

1423

171

0.111/27.3

Nonsense

49

73

27

0.052

Liver

Synonymous

34

43

5

 

Non-synonymous

199

727

99

0.980/14.4

Nonsense

29

50

16

0.040

Lung

Synonymous

56

88

17

 

Non-synonymous

314

1599

191

0.959/17.9

Nonsense

55

170

31

0.042

Pancreas

Synonymous

10

12

1

 

Non-synonymous

106

215

30

0.049/1.56

Nonsense

10

17

6

0.058

Ovary

Synonymous

20

21

1

 

Non-synonymous

192

770

99

0.995/15.7

Nonsense

30

71

12

0.012

Prostate

Synonymous

28

38

7

 

Non-synonymous

114

195

38

0.926/0.72

Nonsense

9

12

2

0.008

Colon

Synonymous

23

28

4

 

Non-synonymous

173

592

69

1.000/4.4

Nonsense

19

60

5

0.016

Colorectal

Synonymous

25

28

4

 

Non-synonymous

203

1097

121

0.000/20.3

Nonsense

29

103

12

0.953

Esophagus

Synonymous

25

32

7

 

Non-synonymous

215

1064

117

0.025/6.26

Nonsense

50

150

27

0.032

Hematopoietic

Synonymous

26

29

3

 

Non-synonymous

202

723

99

0.037/13.08

Nonsense

20

37

5

0.018

Larynx

Synonymous

8

10

2

 

Non-synonymous

108

234

42

1.000/0.60

Nonsense

18

24

5

0.007

Mouth

Synonymous

28

41

9

 

Non-synonymous

176

413

79

0.988/1.59

Nonsense

33

53

10

0.901

Skin

Synonymous

64

136

12

 

Non-synonymous

248

563

99

0.931/9.94

Nonsense

25

69

12

0.025

Stomach

Synonymous

44

64

15

 

Non-synonymous

195

617

88

0.115/1.78

Nonsense

21

52

8

0.029

  1. In the last column, the P-value for the NSMC test (numerator) and the χ2 value for the NSCS test (denominator) are shown along with the NSMC test P-value for the hotspots in nonsense sites. The statistically significant values (rejection of H0) are shown in bold type.