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Table 1 NSMC and NSCS test results for TP53 somatic mutation spectra (H0: mutational bias; H1: selectional bias)

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

  Sites Mutations Hotspots P(H1)/χ2
Bladder
Synonymous 61 80 12  
Non-synonymous 240 775 110 0.107/13.8
Nonsense 36 85 26 0.038
Brain
Synonymous 20 23 2  
Non-synonymous 199 812 98 0.998/11.2
Nonsense 14 32 5 0.015
Breast
Synonymous 77 108 19  
Non-synonymous 294 1423 171 0.111/27.3
Nonsense 49 73 27 0.052
Liver
Synonymous 34 43 5  
Non-synonymous 199 727 99 0.980/14.4
Nonsense 29 50 16 0.040
Lung
Synonymous 56 88 17  
Non-synonymous 314 1599 191 0.959/17.9
Nonsense 55 170 31 0.042
Pancreas
Synonymous 10 12 1  
Non-synonymous 106 215 30 0.049/1.56
Nonsense 10 17 6 0.058
Ovary
Synonymous 20 21 1  
Non-synonymous 192 770 99 0.995/15.7
Nonsense 30 71 12 0.012
Prostate
Synonymous 28 38 7  
Non-synonymous 114 195 38 0.926/0.72
Nonsense 9 12 2 0.008
Colon
Synonymous 23 28 4  
Non-synonymous 173 592 69 1.000/4.4
Nonsense 19 60 5 0.016
Colorectal
Synonymous 25 28 4  
Non-synonymous 203 1097 121 0.000/20.3
Nonsense 29 103 12 0.953
Esophagus
Synonymous 25 32 7  
Non-synonymous 215 1064 117 0.025/6.26
Nonsense 50 150 27 0.032
Hematopoietic
Synonymous 26 29 3  
Non-synonymous 202 723 99 0.037/13.08
Nonsense 20 37 5 0.018
Larynx
Synonymous 8 10 2  
Non-synonymous 108 234 42 1.000/0.60
Nonsense 18 24 5 0.007
Mouth
Synonymous 28 41 9  
Non-synonymous 176 413 79 0.988/1.59
Nonsense 33 53 10 0.901
Skin
Synonymous 64 136 12  
Non-synonymous 248 563 99 0.931/9.94
Nonsense 25 69 12 0.025
Stomach
Synonymous 44 64 15  
Non-synonymous 195 617 88 0.115/1.78
Nonsense 21 52 8 0.029
  1. In the last column, the P-value for the NSMC test (numerator) and the χ2 value for the NSCS test (denominator) are shown along with the NSMC test P-value for the hotspots in nonsense sites. The statistically significant values (rejection of H0) are shown in bold type.