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Figure 8 | Biology Direct

Figure 8

From: Proteomic and bioinformatic analysis of epithelial tight junction reveals an unexpected cluster of synaptic molecules

Figure 8

Analysis of synaptic hits. (A) Categorization of 202 synaptic hits based on synaptic localizations. (B) Sub-categorization of 202 synaptic hits based on synaptic functions. (C) Confocal images showing immunofluorescence localization of presynaptic P/Q-type voltage-gated calcium channel subunit CPα1A and postsynaptic AMPA receptor subunit GluR1 to tight junctions of C2bbE1 intestinal epithelial cells (4 weeks post-confluent). Tight junction formation has been monitored by measurement of transepithelial electrical resistance before the cells are utilized for staining. Occludin is used as a marker for tight junction domain. Merged yellow images show overlapping of occludin and synaptic proteins.

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