Figure 3
From: The immune-body cytokine network defines a social architecture of cell interactions
Immune and body three-cell network structures. a, The numbers of instances in which each type of immune cell participates in the clique and semi-clique motifs are shown. The three cells in the clique triad (upper panel) have no distinction between the connectivities of the participating cells (coded black bars). In contrast, each of the three nodes in the semi-clique (lower panel) has a distinct connectivity role (coded white, black or grey). b, Social cytokine architecture of immune cells. Combining all the instances of the clique and semi-clique triads occurring in the immune sub-network generates a five-tiered social hierarchy of immune cells by their mutual (black, full) and one-way (red, dashed) connectivities to the other nodes. c, Social cytokine architecture of body cells. Combining all the instances of the triads occurring in the body sub-network by their mutual (black, full) and one-way (red, dashed) connectivities to the other nodes generates a connectivity structure that appears quite different from that of the immune cells; see text for discussion.