Skip to main content
Figure 1 | Biology Direct

Figure 1

From: Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires

Figure 1

Clonal lineage analysis of selected Fab families showing implied relationships based on shared mutations. A) Clustal guide tree generated from an alignment of all clonally related VH3-15 H chains isolated from donor 003 PPS 6B-specific Fabs. Fabs marked with an asterisk (*) all have a 2 codon insertion in the VH CDR2 region. B) Clustal guide tree generated from an alignment of all clonally related V1-4 lambda L chains isolated from donor 023 PPS 6B-specific Fabs. Fab marked with an asterisk (*) has a 1 codon insertion in the L chain FR2 region. C) Clustal guide tree generated from an alignment of all clonally related B3 kappa L chains isolated from donor 010 PPS 6B-specific Fabs. Fab marked with an asterisk (*) has a 6 codon deletion in the L chain CDR1 region.

Back to article page

Biology Direct

ISSN: 1745-6150

Contact us