Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samples

Table 4 Significant differences of conditional selection pressure between Treated and Untreated dataset

Codon X	Codon Y	Treated			Untreated			p-value
		(K_a/K_s)_Y\|Xa	N_XaYa	N_XaYs	(K_a/K_s)_Y\|Xa	N_XaYa	N_XaYs
20	10	5.21	74	7	0.08	1	6	0.000021
82	10	10.78	197	9	0.49	4	4	0.000512
71	10	4.39	285	32	0.42	23	27	<0.000001
24	10	25.12	51	0	0.25	2	4	0.000038
12	19	18.25	35	3	3.85	59	24	0.006913
10	54	7.81	164	9	0.19	4	9	<0.000001
71	54	3.65	162	19	0.14	4	12	<0.000001
10	63	12.42	353	14	2.15	70	16	0.000012
93	63	21.23	431	10	6.72	382	28	0.000995
36	71	24.13	196	4	0.46	14	15	<0.000001
63	73	2.76	112	20	0.10	4	19	<0.000001
71	82	10.73	196	9	0.59	6	5	0.000199
63	90	18.32	359	23	0.34	9	31	<0.000001

Due to the long list of significant shift results, only the 13 shifts that involved a positive conditional selection in Treated datasets are listed in this table.

ISSN: 1745-6150